Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
1_MAPIG 6_ LKAVV 11_ GEKIM 16_ HDVIK 21_ KVKKK 26_ GEWKV 31_ LVVDQ 36_ LSMRM 41_ LSSCC 46_ KMTDI 51_ MTEGI 56_ TIVED 61_ INKRR 66_ EPLPS 71_ LEAVY 76_ LITPS 81_ EKSVH 86_ SLISD 91_ FKDPP 96_ TAKYR 101_ AAHVF 106_ FTDSC 111_ PDALF 116_ NELVK 121_ SRAAK 126_ VIKTL 131_ TEINI 136_ AFLPY 141_ ESQVY 146_ SLDSA 151_ DSFQS 156_ FYSPH 161_ KAQMK 166_ NPILE 171_ RLAEQ 176_ IATLC 181_ ATLKE 186_ YPAVR 191_ YRGEY 196_ KDNAL 201_ LAQLI 206_ QDKLD 211_ AYKAD 216_ DPTMG 221_ EGPDK 226_ ARSQL 231_ LILDR 236_ GFDPS 241_ SPVLH 246_ ELTFQ 251_ AMSYD 256_ LLPIE 261_ NDVYK 266_ YETSG 271_ IGEAR 276_ VKEVL 281_ LDEDD 286_ DLWIA 291_ LRHKH 296_ IAEVS 301_ QEVTR 306_ SLKDF 311_ SSSKR 316_ MNTGE 321_ KTTMR 326_ DLSQM 331_ LKKMP 336_ QYQKE 341_ LSKYS 346_ THLHL 351_ AEDCM 356_ KHYQG 361_ TVDKL 366_ CRVEQ 371_ DLAMG 376_ TDAEG 381_ EKIKD 386_ PMRAI 391_ VPILL 396_ DANVS 401_ TYDKI 406_ RIILL 411_ YIFLK 416_ NGITE 421_ ENLNK 426_ LIQHA 431_ QIPPE 436_ DSEII 441_ TNMAH 446_ LGVPI 451_ VTDST 456_ LRRRS 461_ KPERK 466_ ERISE 471_ QTYQL 476_ SRWTP 481_ IIKDI 486_ MEDTI 491_ EDKLD 496_ TKHYP 501_ YISTR 506_ SSASF 511_ STTAV 516_ SARYG 521_ HWHKN 526_ KAPGE 531_ YRSGP 536_ RLIIF 541_ ILGGV 546_ SLNEM 551_ RCAYE 556_ VTQAN 561_ GKWEV 566_ LIGST 571_ HILTP 576_ QKLLD 581_ TLKKL 586_NKTDE
1: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions