Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
1_MSRSV 6_ ALAVL 11_ ALLSL 16_ SGLEA 21_ IQRTP 26_ KIQVY 31_ SRHPA 36_ ENGKS 41_ NFLNC 46_ YVSGF 51_ HPSDI 56_ EVDLL 61_ KNGER 66_ IEKVE 71_ HSDLS 76_ FSKDW 81_ SFYLL 86_ YYTEF 91_ TPTEK 96_ DEYAC 101_ RVNHV 106_ TLSQP 111_KIVKW
1: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553)