Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1)
1_MSASV 6_ VSVIS 11_ RFLEE 16_ YLSST 21_ PQRLK 26_ LLDAY 31_ LLYIL 36_ LTGAL 41_ QFGYC 46_ LLVGT 51_ FPFNS 56_ FLSGF 61_ ISCVG 66_ SFILA 71_ VCLRI 76_ QINPQ 81_ NKADF 86_ QGISP 91_ ERAFA 96_ DFLFA 101_ STILH 106_LVVMN
1: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853)