Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
1_MHYCV 6_ LSAFL 11_ ILHLV 16_ TVALS 21_ LSTCS 26_ TLDMD 31_ QFMRK 36_ RIEAI 41_ RGQIL 46_ SKLKL 51_ TSPPE 56_ DYPEP 61_ EEVPP 66_ EVISI 71_ YNSTR 76_ DLLQE 81_ KASRR 86_ AAACE 91_ RERSD 96_ EEYYA 101_ KEVYK 106_ IDMPP 111_ FFPSE 116_ NAIPP 121_ TFYRP 126_ YFRIV 131_ RFDVS 136_ AMEKN 141_ ASNLV 146_ KAEFR 151_ VFRLQ 156_ NPKAR 161_ VPEQR 166_ IELYQ 171_ ILKSK 176_ DLTSP 181_ TQRYI 186_ DSKVV 191_ KTRAE 196_ GEWLS 201_ FDVTD 206_ AVHEW 211_ LHHKD 216_ RNLGF 221_ KISLH 226_ CPCCT 231_ FVPSN 236_ NYIIP 241_ NKSEE 246_ LEARF 251_ AGIDG 256_ TSTYT 261_ SGDQK 266_ TIKST 271_ RKKNS 276_ GKTPH 281_ LLLML 286_ LPSYR 291_ LESQQ 296_ TNRRK 301_ KRALD 306_ AAYCF 311_ RNVQD 316_ NCCLR 321_ PLYID 326_ FKRDL 331_ GWKWI 336_ HEPKG 341_ YNANF 346_ CAGAC 351_ PYLWS 356_ SDTQH 361_ SRVLS 366_ LYNTI 371_ NPEAS 376_ ASPCC 381_ VSQDL 386_ EPLTI 391_ LYYIG 396_ KTPKI 401_ EQLSN 406_MIVKS
1: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively
2: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity)
3: Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772368, PubMed:22772371). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)