NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein)
1_MRFLA 6_ ATFLL 11_ LALST 16_ AAQAE 21_ PVQFK 26_ DCGSV 31_ DGVIK 36_ EVNVS 41_ PCPTQ 46_ PCQLS 51_ KGQSY 56_ SVNVT 61_ FTSNI 66_ QSKSS 71_ KAVVH 76_ GILMG 81_ VPVPF 86_ PIPEP 91_ DGCKS 96_ GINCP 101_ IQKDK 106_ TYSYL 111_ NKLPV 116_ KSEYP 121_ SIKLV 126_ VEWQL 131_ QDDKN 136_ QSLFC 141_ WEIPV 146_QIVSH
1: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)