Gene name: UFM1

Uniprot entry:

P61960

Protein names:

Ubiquitin-fold modifier 1

Protein sequence:

1_MSKVS 6_ FKITL 11_ TSDPR 16_ LPYKV 21_ LSVPE 26_ STPFT 31_ AVLKF 36_ AAEEF 41_ KVPAA 46_ TSAII 51_ TNDGI 56_ GINPA 61_ QTAGN 66_ VFLKH 71_ GSELR 76_IIPRD

Protein annotations

Protein functions:

1: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:27653677, PubMed:29868776, PubMed:30626644, PubMed:38377992, PubMed:38383785). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:27653677, PubMed:29868776). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:25219498, PubMed:32160526, PubMed:38383785)