Gene name: DCAF7

Uniprot entry:

P61962

Protein names:

DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)

Protein sequence:

1_MSLHG 6_ KRKEI 11_ YKYEA 16_ PWTVY 21_ AMNWS 26_ VRPDK 31_ RFRLA 36_ LGSFV 41_ EEYNN 46_ KVQLV 51_ GLDEE 56_ SSEFI 61_ CRNTF 66_ DHPYP 71_ TTKLM 76_ WIPDT 81_ KGVYP 86_ DLLAT 91_ SGDYL 96_ RVWRV 101_ GETET 106_ RLECL 111_ LNNNK 116_ NSDFC 121_ APLTS 126_ FDWNE 131_ VDPYL 136_ LGTSS 141_ IDTTC 146_ TIWGL 151_ ETGQV 156_ LGRVN 161_ LVSGH 166_ VKTQL 171_ IAHDK 176_ EVYDI 181_ AFSRA 186_ GGGRD 191_ MFASV 196_ GADGS 201_ VRMFD 206_ LRHLE 211_ HSTII 216_ YEDPQ 221_ HHPLL 226_ RLCWN 231_ KQDPN 236_ YLATM 241_ AMDGM 246_ EVVIL 251_ DVRVP 256_ CTPVA 261_ RLNNH 266_ RACVN 271_ GIAWA 276_ PHSSC 281_ HICTA 286_ ADDHQ 291_ ALIWD 296_ IQQMP 301_ RAIED 306_ PILAY 311_ TAEGE 316_ INNVQ 321_ WASTQ 326_ PDWIA 331_ ICYNN 336_CLEIL

Protein annotations

Protein functions:

1: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex