WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
1_MATEE 6_ KKPET 11_ EAARA 16_ QPTPS 21_ SSATQ 26_ SKPTP 31_ VKPNY 36_ ALKFT 41_ LAGHT 46_ KAVSS 51_ VKFSP 56_ NGEWL 61_ ASSSA 66_ DKLIK 71_ IWGAY 76_ DGKFE 81_ KTISG 86_ HKLGI 91_ SDVAW 96_ SSDSN 101_ LLVSA 106_ SDDKT 111_ LKIWD 116_ VSSGK 121_ CLKTL 126_ KGHSN 131_ YVFCC 136_ NFNPQ 141_ SNLIV 146_ SGSFD 151_ ESVRI 156_ WDVKT 161_ GKCLK 166_ TLPAH 171_ SDPVS 176_ AVHFN 181_ RDGSL 186_ IVSSS 191_ YDGLC 196_ RIWDT 201_ ASGQC 206_ LKTLI 211_ DDDNP 216_ PVSFV 221_ KFSPN 226_ GKYIL 231_ AATLD 236_ NTLKL 241_ WDYSK 246_ GKCLK 251_ TYTGH 256_ KNEKY 261_ CIFAN 266_ FSVTG 271_ GKWIV 276_ SGSED 281_ NLVYI 286_ WNLQT 291_ KEIVQ 296_ KLQGH 301_ TDVVI 306_ STACH 311_ PTENI 316_ IASAA 321_ LENDK 326_TIKLW
1: Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)