Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
1_METEQ 6_ PEETF 11_ PNTET 16_ NGEFG 21_ KRPAE 26_ DMEEE 31_ QAFKR 36_ SRNTD 41_ EMVEL 46_ RILLQ 51_ SKNAG 56_ AVIGK 61_ GGKNI 66_ KALRT 71_ DYNAS 76_ VSVPD 81_ SSGPE 86_ RILSI 91_ SADIE 96_ TIGEI 101_ LKKII 106_ PTLEE 111_ GLQLP 116_ SPTAT 121_ SQLPL 126_ ESDAV 131_ ECLNY 136_ QHYKG 141_ SDFDC 146_ ELRLL 151_ IHQSL 156_ AGGII 161_ GVKGA 166_ KIKEL 171_ RENTQ 176_ TTIKL 181_ FQECC 186_ PHSTD 191_ RVVLI 196_ GGKPD 201_ RVVEC 206_ IKIIL 211_ DLISE 216_ SPIKG 221_ RAQPY 226_ DPNFY 231_ DETYD 236_ YGGFT 241_ MMFDD 246_ RRGRP 251_ VGFPM 256_ RGRGG 261_ FDRMP 266_ PGRGG 271_ RPMPP 276_ SRRDY 281_ DDMSP 286_ RRGPP 291_ PPPPG 296_ RGGRG 301_ GSRAR 306_ NLPLP 311_ PPPPP 316_ RGGDL 321_ MAYDR 326_ RGRPG 331_ DRYDG 336_ MVGFS 341_ ADETW 346_ DSAID 351_ TWSPS 356_ EWQMA 361_ YEPQG 366_ GSGYD 371_ YSYAG 376_ GRGSY 381_ GDLGG 386_ PIITT 391_ QVTIP 396_ KDLAG 401_ SIIGK 406_ GGQRI 411_ KQIRH 416_ ESGAS 421_ IKIDE 426_ PLEGS 431_ EDRII 436_ TITGT 441_ QDQIQ 446_ NAQYL 451_ LQNSV 456_KQYSG
1: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841)