14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
1_MVDRE 6_ QLVQK 11_ ARLAE 16_ QAERY 21_ DDMAA 26_ AMKNV 31_ TELNE 36_ PLSNE 41_ ERNLL 46_ SVAYK 51_ NVVGA 56_ RRSSW 61_ RVISS 66_ IEQKT 71_ SADGN 76_ EKKIE 81_ MVRAY 86_ REKIE 91_ KELEA 96_ VCQDV 101_ LSLLD 106_ NYLIK 111_ NCSET 116_ QYESK 121_ VFYLK 126_ MKGDY 131_ YRYLA 136_ EVATG 141_ EKRAT 146_ VVESS 151_ EKAYS 156_ EAHEI 161_ SKEHM 166_ QPTHP 171_ IRLGL 176_ ALNYS 181_ VFYYE 186_ IQNAP 191_ EQACH 196_ LAKTA 201_ FDDAI 206_ AELDT 211_ LNEDS 216_ YKDST 221_ LIMQL 226_ LRDNL 231_ TLWTS 236_ DQQDD 241_DGGEG
1: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927)