Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)
1_MTVRN 6_ IASIC 11_ NMGTN 16_ ASALE 21_ KDIGP 26_ EQFPI 31_ NEHYF 36_ GLVNF 41_ GNTCY 46_ CNSVL 51_ QALYF 56_ CRPFR 61_ ENVLA 66_ YKAQQ 71_ KKKEN 76_ LLTCL 81_ ADLFH 86_ SIATQ 91_ KKKVG 96_ VIPPK 101_ KFISR 106_ LRKEN 111_ DLFDN 116_ YMQQD 121_ AHEFL 126_ NYLLN 131_ TIADI 136_ LQEEK 141_ KQEKQ 146_ NGKLK 151_ NGNMN 156_ EPAEN 161_ NKPEL 166_ TWVHE 171_ IFQGT 176_ LTNET 181_ RCLNC 186_ ETVSS 191_ KDEDF 196_ LDLSV 201_ DVEQN 206_ TSITH 211_ CLRDF 216_ SNTET 221_ LCSEQ 226_ KYYCE 231_ TCCSK 236_ QEAQK 241_ RMRVK 246_ KLPMI 251_ LALHL 256_ KRFKY 261_ MEQLH 266_ RYTKL 271_ SYRVV 276_ FPLEL 281_ RLFNT 286_ SSDAV 291_ NLDRM 296_ YDLVA 301_ VVVHC 306_ GSGPN 311_ RGHYI 316_ TIVKS 321_ HGFWL 326_ LFDDD 331_ IVEKI 336_ DAQAI 341_ EEFYG 346_ LTSDI 351_ SKNSE 356_ SGYIL 361_FYQSR
1: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014)