Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
1_MSGKH 6_ YKGPE 11_ VSCCI 16_ KYFIF 21_ GFNVI 26_ FWFLG 31_ ITFLG 36_ IGLWA 41_ WNEKG 46_ VLSNI 51_ SSITD 56_ LGGFD 61_ PVWLF 66_ LVVGG 71_ VMFIL 76_ GFAGC 81_ IGALR 86_ ENTFL 91_ LKFFS 96_ VFLGI 101_ IFFLE 106_ LTAGV 111_ LAFVF 116_ KDWIK 121_ DQLYF 126_ FINNN 131_ IRAYR 136_ DDIDL 141_ QNLID 146_ FTQEY 151_ WQCCG 156_ AFGAD 161_ DWNLN 166_ IYFNC 171_ TDSNA 176_ SRERC 181_ GVPFS 186_ CCTKD 191_ PAEDV 196_ INTQC 201_ GYDAR 206_ QKPEV 211_ DQQIV 216_ IYTKG 221_ CVPQF 226_ EKWLQ 231_ DNLTI 236_ VAGIF 241_ IGIAL 246_ LQIFG 251_ ICLAQ 256_ NLVSD 261_IEAVR
1: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:28600292, PubMed:37516108). Promotes ADAM10-mediated cleavage of CD44 (PubMed:26686862). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (PubMed:28600292)