Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
1_MADGE 6_ LNVDS 11_ LITRL 16_ LEVRG 21_ CRPGK 26_ IVQMT 31_ EAEVR 36_ GLCIK 41_ SREIF 46_ LSQPI 51_ LLELE 56_ APLKI 61_ CGDIH 66_ GQYTD 71_ LLRLF 76_ EYGGF 81_ PPEAN 86_ YLFLG 91_ DYVDR 96_ GKQSL 101_ ETICL 106_ LLAYK 111_ IKYPE 116_ NFFLL 121_ RGNHE 126_ CASIN 131_ RIYGF 136_ YDECK 141_ RRFNI 146_ KLWKT 151_ FTDCF 156_ NCLPI 161_ AAIVD 166_ EKIFC 171_ CHGGL 176_ SPDLQ 181_ SMEQI 186_ RRIMR 191_ PTDVP 196_ DTGLL 201_ CDLLW 206_ SDPDK 211_ DVQGW 216_ GENDR 221_ GVSFT 226_ FGADV 231_ VSKFL 236_ NRHDL 241_ DLICR 246_ AHQVV 251_ EDGYE 256_ FFAKR 261_ QLVTL 266_ FSAPN 271_ YCGEF 276_ DNAGG 281_ MMSVD 286_ ETLMC 291_ SFQIL 296_ KPSEK 301_ KAKYQ 306_ YGGLN 311_ SGRPV 316_ TPPRT 321_ANPPK
1: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670)