26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
1_MGQSQ 6_ SGGHG 11_ PGGGK 16_ KDDKD 21_ KKKKY 26_ EPPVP 31_ TRVGK 36_ KKKKT 41_ KGPDA 46_ ASKLP 51_ LVTPH 56_ TQCRL 61_ KLLKL 66_ ERIKD 71_ YLLME 76_ EEFIR 81_ NQEQM 86_ KPLEE 91_ KQEEE 96_ RSKVD 101_ DLRGT 106_ PMSVG 111_ TLEEI 116_ IDDNH 121_ AIVST 126_ SVGSE 131_ HYVSI 136_ LSFVD 141_ KDLLE 146_ PGCSV 151_ LLNHK 156_ VHAVI 161_ GVLMD 166_ DTDPL 171_ VTVMK 176_ VEKAP 181_ QETYA 186_ DIGGL 191_ DNQIQ 196_ EIKES 201_ VELPL 206_ THPEY 211_ YEEMG 216_ IKPPK 221_ GVILY 226_ GPPGT 231_ GKTLL 236_ AKAVA 241_ NQTSA 246_ TFLRV 251_ VGSEL 256_ IQKYL 261_ GDGPK 266_ LVREL 271_ FRVAE 276_ EHAPS 281_ IVFID 286_ EIDAI 291_ GTKRY 296_ DSNSG 301_ GEREI 306_ QRTML 311_ ELLNQ 316_ LDGFD 321_ SRGDV 326_ KVIMA 331_ TNRIE 336_ TLDPA 341_ LIRPG 346_ RIDRK 351_ IEFPL 356_ PDEKT 361_ KKRIF 366_ QIHTS 371_ RMTLA 376_ DDVTL 381_ DDLIM 386_ AKDDL 391_ SGADI 396_ KAICT 401_ EAGLM 406_ ALRER 411_ RMKVT 416_ NEDFK 421_ KSKEN 426_ VLYKK 431_QEGTP
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides