26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
1_MALDG 6_ PEQME 11_ LEEGK 16_ AGSGL 21_ RQYYL 26_ SKIEE 31_ LQLIV 36_ NDKSQ 41_ NLRRL 46_ QAQRN 51_ ELNAK 56_ VRLLR 61_ EELQL 66_ LQEQG 71_ SYVGE 76_ VVRAM 81_ DKKKV 86_ LVKVH 91_ PEGKF 96_ VVDVD 101_ KNIDI 106_ NDVTP 111_ NCRVA 116_ LRNDS 121_ YTLHK 126_ ILPNK 131_ VDPLV 136_ SLMMV 141_ EKVPD 146_ STYEM 151_ IGGLD 156_ KQIKE 161_ IKEVI 166_ ELPVK 171_ HPELF 176_ EALGI 181_ AQPKG 186_ VLLYG 191_ PPGTG 196_ KTLLA 201_ RAVAH 206_ HTDCT 211_ FIRVS 216_ GSELV 221_ QKFIG 226_ EGARM 231_ VRELF 236_ VMARE 241_ HAPSI 246_ IFMDE 251_ IDSIG 256_ SSRLE 261_ GGSGG 266_ DSEVQ 271_ RTMLE 276_ LLNQL 281_ DGFEA 286_ TKNIK 291_ VIMAT 296_ NRIDI 301_ LDSAL 306_ LRPGR 311_ IDRKI 316_ EFPPP 321_ NEEAR 326_ LDILK 331_ IHSRK 336_ MNLTR 341_ GINLR 346_ KIAEL 351_ MPGAS 356_ GAEVK 361_ GVCTE 366_ AGMYA 371_ LRERR 376_ VHVTQ 381_ EDFEM 386_ AVAKV 391_ MQKDS 396_ EKNMS 401_IKKLW
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides