Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
1_MSSPS 6_ PGKRR 11_ MDTDV 16_ VKLIE 21_ SKHEV 26_ TILGG 31_ LNEFV 36_ VKFYG 41_ PQGTP 46_ YEGGV 51_ WKVRV 56_ DLPDK 61_ YPFKS 66_ PSIGF 71_ MNKIF 76_ HPNID 81_ EASGT 86_ VCLDV 91_ INQTW 96_ TALYD 101_ LTNIF 106_ ESFLP 111_ QLLAY 116_ PNPID 121_ PLNGD 126_ AAAMY 131_ LHRPE 136_ EYKQK 141_ IKEYI 146_ QKYAT 151_ EEALK 156_ EQEEG 161_ TGDSS 166_ SESSM 171_ SDFSE 176_DEAQD
1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:17588522, PubMed:20061386, PubMed:8132613). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613)