14-3-3 protein epsilon (14-3-3E)
1_MDDRE 6_ DLVYQ 11_ AKLAE 16_ QAERY 21_ DEMVE 26_ SMKKV 31_ AGMDV 36_ ELTVE 41_ ERNLL 46_ SVAYK 51_ NVIGA 56_ RRASW 61_ RIISS 66_ IEQKE 71_ ENKGG 76_ EDKLK 81_ MIREY 86_ RQMVE 91_ TELKL 96_ ICCDI 101_ LDVLD 106_ KHLIP 111_ AANTG 116_ ESKVF 121_ YYKMK 126_ GDYHR 131_ YLAEF 136_ ATGND 141_ RKEAA 146_ ENSLV 151_ AYKAA 156_ SDIAM 161_ TELPP 166_ THPIR 171_ LGLAL 176_ NFSVF 181_ YYEIL 186_ NSPDR 191_ ACRLA 196_ KAAFD 201_ DAIAE 206_ LDTLS 211_ EESYK 216_ DSTLI 221_ MQLLR 226_ DNLTL 231_ WTSDM 236_ QGDGE 241_ EQNKE 246_ALQDV
1: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448)