40S ribosomal protein S23 (Small ribosomal subunit protein uS12)
1_MGKCR 6_ GLRTA 11_ RKLRS 16_ HRRDQ 21_ KWHDK 26_ QYKKA 31_ HLGTA 36_ LKANP 41_ FGGAS 46_ HAKGI 51_ VLEKV 56_ GVEAK 61_ QPNSA 66_ IRKCV 71_ RVQLI 76_ KNGKK 81_ ITAFV 86_ PNDGC 91_ LNFIE 96_ ENDEV 101_ LVAGF 106_ GRKGH 111_ AVGDI 116_ PGVRF 121_ KVVKV 126_ ANVSL 131_ LALYK 136_GKKER
1: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:28257692). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:25957688). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:25957688). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25901680, PubMed:25957688). Plays an important role in translational accuracy (PubMed:28257692). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)