Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1)
1_MKLVR 6_ FLMKL 11_ SHETV 16_ TIELK 21_ NGTQV 26_ HGTIT 31_ GVDVS 36_ MNTHL 41_ KAVKM 46_ TLKNR 51_ EPVQL 56_ ETLSI 61_ RGNNI 66_ RYFIL 71_ PDSLP 76_ LDTLL 81_ VDVEP 86_ KVKSK 91_ KREAV 96_ AGRGR 101_ GRGRG 106_ RGRGR 111_GRGRG
1: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303)