26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
1_MADPR 6_ DKALQ 11_ DYRKK 16_ LLEHK 21_ EIDGR 26_ LKELR 31_ EQLKE 36_ LTKQY 41_ EKSEN 46_ DLKAL 51_ QSVGQ 56_ IVGEV 61_ LKQLT 66_ EEKFI 71_ VKATN 76_ GPRYV 81_ VGCRR 86_ QLDKS 91_ KLKPG 96_ TRVAL 101_ DMTTL 106_ TIMRY 111_ LPREV 116_ DPLVY 121_ NMSHE 126_ DPGNV 131_ SYSEI 136_ GGLSE 141_ QIREL 146_ REVIE 151_ LPLTN 156_ PELFQ 161_ RVGII 166_ PPKGC 171_ LLYGP 176_ PGTGK 181_ TLLAR 186_ AVASQ 191_ LDCNF 196_ LKVVS 201_ SSIVD 206_ KYIGE 211_ SARLI 216_ REMFN 221_ YARDH 226_ QPCII 231_ FMDEI 236_ DAIGG 241_ RRFSE 246_ GTSAD 251_ REIQR 256_ TLMEL 261_ LNQMD 266_ GFDTL 271_ HRVKM 276_ IMATN 281_ RPDTL 286_ DPALL 291_ RPGRL 296_ DRKIH 301_ IDLPN 306_ EQARL 311_ DILKI 316_ HAGPI 321_ TKHGE 326_ IDYEA 331_ IVKLS 336_ DGFNG 341_ ADLRN 346_ VCTEA 351_ GMFAI 356_ RADHD 361_ FVVQE 366_ DFMKA 371_ VRKVA 376_ DSKKL 381_ESKLD
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides