DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)
1_MFYHI 6_ SLEHE 11_ ILLHP 16_ RYFGP 21_ NLLNT 26_ VKQKL 31_ FTEVE 36_ GTCTG 41_ KYGFV 46_ IAVTT 51_ IDNIG 56_ AGVIQ 61_ PGRGF 66_ VLYPV 71_ KYKAI 76_ VFRPF 81_ KGEVV 86_ DAVVT 91_ QVNKV 96_ GLFTE 101_ IGPMS 106_ CFISR 111_ HSIPS 116_ EMEFD 121_ PNSNP 126_ PCYKT 131_ MDEDI 136_ VIQQD 141_ DEIRL 146_ KIVGT 151_ RVDKN 156_ DIFAI 161_ GSLMD 166_DYLGL
1: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA