Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)
1_MADDP 6_ SAADR 11_ NVEIW 16_ KIKKL 21_ IKSLE 26_ AARGN 31_ GTSMI 36_ SLIIP 41_ PKDQI 46_ SRVAK 51_ MLADE 56_ FGTAS 61_ NIKSR 66_ VNRLS 71_ VLGAI 76_ TSVQQ 81_ RLKLY 86_ NKVPP 91_ NGLVV 96_ YCGTI 101_ VTEEG 106_ KEKKV 111_ NIDFE 116_ PFKPI 121_ NTSLY 126_ LCDNK 131_ FHTEA 136_ LTALL 141_ SDDSK 146_ FGFIV 151_ IDGSG 156_ ALFGT 161_ LQGNT 166_ REVLH 171_ KFTVD 176_ LPKKH 181_ GRGGQ 186_ SALRF 191_ ARLRM 196_ EKRHN 201_ YVRKV 206_ AETAV 211_ QLFIS 216_ GDKVN 221_ VAGLV 226_ LAGSA 231_ DFKTE 236_ LSQSD 241_ MFDQR 246_ LQSKV 251_ LKLVD 256_ ISYGG 261_ ENGFN 266_ QAIEL 271_ STEVL 276_ SNVKF 281_ IQEKK 286_ LIGRY 291_ FDEIS 296_ QDTGK 301_ YCFGV 306_ EDTLK 311_ ALEMG 316_ AVEIL 321_ IVYEN 326_ LDIMR 331_ YVLHC 336_ QGTEE 341_ EKILY 346_ LTPEQ 351_ EKDKS 356_ HFTDK 361_ ETGQE 366_ HELIE 371_ SMPLL 376_ EWFAN 381_ NYKKF 386_ GATLE 391_ IVTDK 396_ SQEGS 401_ QFVKG 406_ FGGIG 411_ GILRY 416_ RVDFQ 421_ GMEYQ 426_ GGDDE 431_FFDLD
1: Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)