Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
1_MDDKA 6_ FTKEL 11_ DQWVE 16_ QLNEC 21_ KQLNE 26_ NQVRT 31_ LCEKA 36_ KEILT 41_ KESNV 46_ QEVRC 51_ PVTVC 56_ GDVHG 61_ QFHDL 66_ MELFR 71_ IGGKS 76_ PDTNY 81_ LFMGD 86_ YVDRG 91_ YYSVE 96_ TVTLL 101_ VALKV 106_ RYPER 111_ ITILR 116_ GNHES 121_ RQITQ 126_ VYGFY 131_ DECLR 136_ KYGNA 141_ NVWKY 146_ FTDLF 151_ DYLPL 156_ TALVD 161_ GQIFC 166_ LHGGL 171_ SPSID 176_ TLDHI 181_ RALDR 186_ LQEVP 191_ HEGPM 196_ CDLLW 201_ SDPDD 206_ RGGWG 211_ ISPRG 216_ AGYTF 221_ GQDIS 226_ ETFNH 231_ ANGLT 236_ LVSRA 241_ HQLVM 246_ EGYNW 251_ CHDRN 256_ VVTIF 261_ SAPNY 266_ CYRCG 271_ NQAAI 276_ MELDD 281_ TLKYS 286_ FLQFD 291_ PAPRR 296_ GEPHV 301_TRRTP
1: Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)