Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
1_MAAIR 6_ KKLVV 11_ VGDGA 16_ CGKTC 21_ LLIVF 26_ SKDEF 31_ PEVYV 36_ PTVFE 41_ NYVAD 46_ IEVDG 51_ KQVEL 56_ ALWDT 61_ AGQED 66_ YDRLR 71_ PLSYP 76_ DTDVI 81_ LMCFS 86_ VDSPD 91_ SLENI 96_ PEKWV 101_ PEVKH 106_ FCPNV 111_ PIILV 116_ ANKKD 121_ LRSDE 126_ HVRTE 131_ LARMK 136_ QEPVR 141_ TDDGR 146_ AMAVR 151_ IQAYD 156_ YLECS 161_ AKTKE 166_ GVREV 171_ FETAT 176_ RAALQ 181_ KRYGS 186_ QNGCI 191_NCCKV
1: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells