GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
1_MAAQG 6_ EPQVQ 11_ FKLVL 16_ VGDGG 21_ TGKTT 26_ FVKRH 31_ LTGEF 36_ EKKYV 41_ ATLGV 46_ EVHPL 51_ VFHTN 56_ RGPIK 61_ FNVWD 66_ TAGQE 71_ KFGGL 76_ RDGYY 81_ IQAQC 86_ AIIMF 91_ DVTSR 96_ VTYKN 101_ VPNWH 106_ RDLVR 111_ VCENI 116_ PIVLC 121_ GNKVD 126_ IKDRK 131_ VKAKS 136_ IVFHR 141_ KKNLQ 146_ YYDIS 151_ AKSNY 156_ NFEKP 161_ FLWLA 166_ RKLIG 171_ DPNLE 176_ FVAMP 181_ ALAPP 186_ EVVMD 191_ PALAA 196_ QYEHD 201_ LEVAQ 206_ TTALP 211_DEDDD
1: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640)