Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
1_MREYK 6_ LVVLG 11_ SGGVG 16_ KSALT 21_ VQFVQ 26_ GIFVE 31_ KYDPT 36_ IEDSY 41_ RKQVE 46_ VDCQQ 51_ CMLEI 56_ LDTAG 61_ TEQFT 66_ AMRDL 71_ YMKNG 76_ QGFAL 81_ VYSIT 86_ AQSTF 91_ NDLQD 96_ LREQI 101_ LRVKD 106_ TEDVP 111_ MILVG 116_ NKCDL 121_ EDERV 126_ VGKEQ 131_ GQNLA 136_ RQWCN 141_ CAFLE 146_ SSAKS 151_ KINVN 156_ EIFYD 161_ LVRQI 166_ NRKTP 171_ VEKKK 176_PKKKS
1: Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions