60S ribosomal protein L11 (CLL-associated antigen KW-12) (Large ribosomal subunit protein uL5)
1_MAQDQ 6_ GEKEN 11_ PMREL 16_ RIRKL 21_ CLNIC 26_ VGESG 31_ DRLTR 36_ AAKVL 41_ EQLTG 46_ QTPVF 51_ SKARY 56_ TVRSF 61_ GIRRN 66_ EKIAV 71_ HCTVR 76_ GAKAE 81_ EILEK 86_ GLKVR 91_ EYELR 96_ KNNFS 101_ DTGNF 106_ GFGIQ 111_ EHIDL 116_ GIKYD 121_ PSIGI 126_ YGLDF 131_ YVVLG 136_ RPGFS 141_ IADKK 146_ RRTGC 151_ IGAKH 156_ RISKE 161_ EAMRW 166_ FQQKY 171_DGIIL
1: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity)