Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
1_MGVQV 6_ ETISP 11_ GDGRT 16_ FPKRG 21_ QTCVV 26_ HYTGM 31_ LEDGK 36_ KFDSS 41_ RDRNK 46_ PFKFM 51_ LGKQE 56_ VIRGW 61_ EEGVA 66_ QMSVG 71_ QRAKL 76_ TISPD 81_ YAYGA 86_ TGHPG 91_ IIPPH 96_ ATLVF 101_DVELL
1: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides