Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
1_MSDSG 6_ EQNYG 11_ ERESR 16_ SASRS 21_ GSAHG 26_ SGKSA 31_ RHTPA 36_ RSRSK 41_ EDSRR 46_ SRSKS 51_ RSRSE 56_ SRSRS 61_ RRSSR 66_ RHYTR 71_ SRSRS 76_ RSHRR 81_ SRSRS 86_ YSRDY 91_ RRRHS 96_ HSHSP 101_ MSTRR 106_ RHVGN 111_ RANPD 116_ PNCCL 121_ GVFGL 126_ SLYTT 131_ ERDLR 136_ EVFSK 141_ YGPIA 146_ DVSIV 151_ YDQQS 156_ RRSRG 161_ FAFVY 166_ FENVD 171_ DAKEA 176_ KERAN 181_ GMELD 186_ GRRIR 191_ VDFSI 196_ TKRPH 201_ TPTPG 206_ IYMGR 211_ PTYGS 216_ SRRRD 221_ YYDRG 226_ YDRGY 231_ DDRDY 236_ YSRSY 241_ RGGGG 246_ GGGGW 251_ RAAQD 256_ RDQIY 261_ RRRSP 266_ SPYYS 271_ RGGYR 276_ SRSRS 281_RSYSP
1: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA