AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
1_MTDSK 6_ YFTTN 11_ KKGEI 16_ FELKA 21_ ELNNE 26_ KKEKR 31_ KEAVK 36_ KVIAA 41_ MTVGK 46_ DVSSL 51_ FPDVV 56_ NCMQT 61_ DNLEL 66_ KKLVY 71_ LYLMN 76_ YAKSQ 81_ PDMAI 86_ MAVNS 91_ FVKDC 96_ EDPNP 101_ LIRAL 106_ AVRTM 111_ GCIRV 116_ DKITE 121_ YLCEP 126_ LRKCL 131_ KDEDP 136_ YVRKT 141_ AAVCV 146_ AKLHD 151_ INAQM 156_ VEDQG 161_ FLDSL 166_ RDLIA 171_ DSNPM 176_ VVANA 181_ VAALS 186_ EISES 191_ HPNSN 196_ LLDLN 201_ PQNIN 206_ KLLTA 211_ LNECT 216_ EWGQI 221_ FILDC 226_ LSNYN 231_ PKDDR 236_ EAQSI 241_ CERVT 246_ PRLSH 251_ ANSAV 256_ VLSAV 261_ KVLMK 266_ FLELL 271_ PKDSD 276_ YYNML 281_ LKKLA 286_ PPLVT 291_ LLSGE 296_ PEVQY 301_ VALRN 306_ INLIV 311_ QKRPE 316_ ILKQE 321_ IKVFF 326_ VKYND 331_ PIYVK 336_ LEKLD 341_ IMIRL 346_ ASQAN 351_ IAQVL 356_ AELKE 361_ YATEV 366_ DVDFV 371_ RKAVR 376_ AIGRC 381_ AIKVE 386_ QSAER 391_ CVSTL 396_ LDLIQ 401_ TKVNY 406_ VVQEA 411_ IVVIR 416_ DIFRK 421_ YPNKY 426_ ESIIA 431_ TLCEN 436_ LDSLD 441_ EPDAR 446_ AAMIW 451_ IVGEY 456_ AERID 461_ NADEL 466_ LESFL 471_ EGFHD 476_ ESTQV 481_ QLTLL 486_ TAIVK 491_ LFLKK 496_ PSETQ 501_ ELVQQ 506_ VLSLA 511_ TQDSD 516_ NPDLR 521_ DRGYI 526_ YWRLL 531_ STDPV 536_ TAKEV 541_ VLSEK 546_ PLISE 551_ ETDLI 556_ EPTLL 561_ DELIC 566_ HIGSL 571_ ASVYH 576_ KPPNA 581_ FVEGS 586_ HGIHR 591_ KHLPI 596_ HHGST 601_ DAGDS 606_ PVGTT 611_ TATNL 616_ EQPQV 621_ IPSQG 626_ DLLGD 631_ LLNLD 636_ LGPPV 641_ NVPQV 646_ SSMQM 651_ GAVDL 656_ LGGGL 661_ DSLVG 666_ QSFIP 671_ SSVPA 676_ TFAPS 681_ PTPAV 686_ VSSGL 691_ NDLFE 696_ LSTGI 701_ GMAPG 706_ GYVAP 711_ KAVWL 716_ PAVKA 721_ KGLEI 726_ SGTFT 731_ HRQGH 736_ IYMEM 741_ NFTNK 746_ ALQHM 751_ TDFAI 756_ QFNKN 761_ SFGVI 766_ PSTPL 771_ AIHTP 776_ LMPNQ 781_ SIDVS 786_ LPLNT 791_ LGPVM 796_ KMEPL 801_ NNLQV 806_ AVKNN 811_ IDVFY 816_ FSCLI 821_ PLNVL 826_ FVEDG 831_ KMERQ 836_ VFLAT 841_ WKDIP 846_ NENEL 851_ QFQIK 856_ ECHLN 861_ ADTVS 866_ SKLQN 871_ NNVYT 876_ IAKRN 881_ VEGQD 886_ MLYQS 891_ LKLTN 896_ GIWIL 901_ AELRI 906_ QPGNP 911_ NYTLS 916_ LKCRA 921_ PEVSQ 926_ YIYQV 931_YDSIL
1: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly