Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
1_MSATA 6_ ATAPP 11_ AAPAG 16_ EGGPP 21_ APPPN 26_ LTSNR 31_ RLQQT 36_ QAQVD 41_ EVVDI 46_ MRVNV 51_ DKVLE 56_ RDQKL 61_ SELDD 66_ RADAL 71_ QAGAS 76_ QFETS 81_ AAKLK 86_ RKYWW 91_ KNLKM 96_ MIILG 101_ VICAI 106_ ILIII 111_IVYFS
1: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1