Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
1_MGCLG 6_ NSKTE 11_ DQRNE 16_ EKAQR 21_ EANKK 26_ IEKQL 31_ QKDKQ 36_ VYRAT 41_ HRLLL 46_ LGAGE 51_ SGKST 56_ IVKQM 61_ RILHV 66_ NGFNG 71_ EGGEE 76_ DPQAA 81_ RSNSD 86_ GEKAT 91_ KVQDI 96_ KNNLK 101_ EAIET 106_ IVAAM 111_ SNLVP 116_ PVELA 121_ NPENQ 126_ FRVDY 131_ ILSVM 136_ NVPDF 141_ DFPPE 146_ FYEHA 151_ KALWE 156_ DEGVR 161_ ACYER 166_ SNEYQ 171_ LIDCA 176_ QYFLD 181_ KIDVI 186_ KQADY 191_ VPSDQ 196_ DLLRC 201_ RVLTS 206_ GIFET 211_ KFQVD 216_ KVNFH 221_ MFDVG 226_ GQRDE 231_ RRKWI 236_ QCFND 241_ VTAII 246_ FVVAS 251_ SSYNM 256_ VIRED 261_ NQTNR 266_ LQEAL 271_ NLFKS 276_ IWNNR 281_ WLRTI 286_ SVILF 291_ LNKQD 296_ LLAEK 301_ VLAGK 306_ SKIED 311_ YFPEF 316_ ARYTT 321_ PEDAT 326_ PEPGE 331_ DPRVT 336_ RAKYF 341_ IRDEF 346_ LRIST 351_ ASGDG 356_ RHYCY 361_ PHFTC 366_ AVDTE 371_ NIRRV 376_ FNDCR 381_ DIIQR 386_MHLRQ
1: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:12391161, PubMed:17110384, PubMed:21488135, PubMed:26206488, PubMed:8702665, PubMed:10200251). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:12391161, PubMed:17110384, PubMed:10200251). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:12391161, PubMed:17110384, PubMed:10200251). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:12391161, PubMed:17110384, PubMed:10200251). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:12391161, PubMed:17110384, PubMed:10200251). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:17110384, PubMed:26206488, PubMed:26206488, PubMed:8702665). Functions downstream of beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161)