Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
1_MGCTL 6_ SAEDK 11_ AAVER 16_ SKMID 21_ RNLRE 26_ DGEKA 31_ AREVK 36_ LLLLG 41_ AGESG 46_ KSTIV 51_ KQMKI 56_ IHEAG 61_ YSEEE 66_ CKQYK 71_ AVVYS 76_ NTIQS 81_ IIAII 86_ RAMGR 91_ LKIDF 96_ GDSAR 101_ ADDAR 106_ QLFVL 111_ AGAAE 116_ EGFMT 121_ AELAG 126_ VIKRL 131_ WKDSG 136_ VQACF 141_ NRSRE 146_ YQLND 151_ SAAYY 156_ LNDLD 161_ RIAQP 166_ NYIPT 171_ QQDVL 176_ RTRVK 181_ TTGIV 186_ ETHFT 191_ FKDLH 196_ FKMFD 201_ VGGQR 206_ SERKK 211_ WIHCF 216_ EGVTA 221_ IIFCV 226_ ALSDY 231_ DLVLA 236_ EDEEM 241_ NRMHE 246_ SMKLF 251_ DSICN 256_ NKWFT 261_ DTSII 266_ LFLNK 271_ KDLFE 276_ EKIKK 281_ SPLTI 286_ CYPEY 291_ AGSNT 296_ YEEAA 301_ AYIQC 306_ QFEDL 311_ NKRKD 316_ TKEIY 321_ THFTC 326_ ATDTK 331_ NVQFV 336_ FDAVT 341_ DVIIK 346_NNLKD
1: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364)