14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
1_MDKNE 6_ LVQKA 11_ KLAEQ 16_ AERYD 21_ DMAAC 26_ MKSVT 31_ EQGAE 36_ LSNEE 41_ RNLLS 46_ VAYKN 51_ VVGAR 56_ RSSWR 61_ VVSSI 66_ EQKTE 71_ GAEKK 76_ QQMAR 81_ EYREK 86_ IETEL 91_ RDICN 96_ DVLSL 101_ LEKFL 106_ IPNAS 111_ QAESK 116_ VFYLK 121_ MKGDY 126_ YRYLA 131_ EVAAG 136_ DDKKG 141_ IVDQS 146_ QQAYQ 151_ EAFEI 156_ SKKEM 161_ QPTHP 166_ IRLGL 171_ ALNFS 176_ VFYYE 181_ ILNSP 186_ EKACS 191_ LAKTA 196_ FDEAI 201_ AELDT 206_ LSEES 211_ YKDST 216_ LIMQL 221_ LRDNL 226_ TLWTS 231_ DTQGD 236_EAEAG
1: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)