Endogenous retrovirus group K member 9 Gag polyprotein (HERV-K(C6) Gag protein) (HERV-K109 Gag protein) (HERV-K_6q14.1 provirus ancestral Gag polyprotein) (Gag polyprotein)
1_MGQTK 6_ SKIKS 11_ KYASY 16_ LSFIK 21_ ILLKR 26_ GGVKV 31_ STKNL 36_ IKLFQ 41_ IIEQF 46_ CPWFP 51_ EQGTL 56_ DLKDW 61_ KRIGK 66_ ELKQA 71_ GRKGN 76_ IIPLT 81_ VWNDW 86_ AIIKA 91_ ALEPF 96_ QTEED 101_ SISVS 106_ DAPGS 111_ GIIDC 116_ NEKTR 121_ KKSQK 126_ ETESL 131_ HCEYV 136_ AEPVM 141_ AQSTQ 146_ NVDYN 151_ QLQEV 156_ IYPET 161_ LKLEG 166_ KGPEL 171_ VGPSE 176_ SKPRG 181_ TSPLP 186_ AGQVP 191_ VTLQP 196_ QKQVK 201_ ENKTQ 206_ PPVAY 211_ QYWPP 216_ AELQY 221_ RPPPE 226_ SQYGY 231_ PGMPP 236_ APQGR 241_ APYPQ 246_ PPTRR 251_ LNPTA 256_ PPSRQ 261_ GSELH 266_ EIIDK 271_ SRKEG 276_ DTEAW 281_ QFPVT 286_ LEPMP 291_ PGEGA 296_ QEGEP 301_ PTVEA 306_ RYKSF 311_ SIKIL 316_ KDMKE 321_ GVKQY 326_ GPNSP 331_ YMRTL 336_ LDSIA 341_ HGHRL 346_ IPYDW 351_ EILAK 356_ SSLSP 361_ SQFLQ 366_ FKTWW 371_ IDGVQ 376_ EQVRR 381_ NRAAN 386_ PPVNI 391_ DADQL 396_ LGIGQ 401_ NWSTI 406_ SQQAL 411_ MQNEA 416_ IEQVR 421_ AICLR 426_ AWEKI 431_ QDPGS 436_ TCPSF 441_ NTVRQ 446_ GSKEP 451_ YPDFV 456_ ARLQD 461_ VAQKS 466_ IADEK 471_ ARKVI 476_ VELMA 481_ YENAN 486_ PECQS 491_ AIKPL 496_ KGKVP 501_ AGSDV 506_ ISEYV 511_ KACDG 516_ IGGAM 521_ HKAML 526_ MAQAI 531_ TGVVL 536_ GGQVR 541_ TFGGK 546_ CYNCG 551_ QIGHL 556_ KKNCP 561_ VLNKQ 566_ NITIQ 571_ ATTTG 576_ REPPD 581_ LCPRC 586_ KKGKH 591_ WASQC 596_ RSKFD 601_ KNGQP 606_ LSGNE 611_ QRGQP 616_ QAPQQ 621_ TGAFP 626_ IQPFV 631_ PQGFQ 636_ GQQPP 641_ LSQVF 646_ QGISQ 651_ LPQYN 656_ NCPPP 661_QVAVQ
1: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution