Endogenous retrovirus group K member 9 Pol protein (HERV-K(C6) Gag-Pol protein) (HERV-K109 Gag-Pol protein) (HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein) [Includes: Protease (EC 3.4.23.50) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT)]
1_MGQTK 6_ SKIKS 11_ KYASY 16_ LSFIK 21_ ILLKR 26_ GGVKV 31_ STKNL 36_ IKLFQ 41_ IIEQF 46_ CPWFP 51_ EQGTL 56_ DLKDW 61_ KRIGK 66_ ELKQA 71_ GRKGN 76_ IIPLT 81_ VWNDW 86_ AIIKA 91_ ALEPF 96_ QTEED 101_ SISVS 106_ DAPGS 111_ GIIDC 116_ NEKTR 121_ KKSQK 126_ ETESL 131_ HCEYV 136_ AEPVM 141_ AQSTQ 146_ NVDYN 151_ QLQEV 156_ IYPET 161_ LKLEG 166_ KGPEL 171_ VGPSE 176_ SKPRG 181_ TSPLP 186_ AGQVP 191_ VTLQP 196_ QKQVK 201_ ENKTQ 206_ PPVAY 211_ QYWPP 216_ AELQY 221_ RPPPE 226_ SQYGY 231_ PGMPP 236_ APQGR 241_ APYPQ 246_ PPTRR 251_ LNPTA 256_ PPSRQ 261_ GSELH 266_ EIIDK 271_ SRKEG 276_ DTEAW 281_ QFPVT 286_ LEPMP 291_ PGEGA 296_ QEGEP 301_ PTVEA 306_ RYKSF 311_ SIKIL 316_ KDMKE 321_ GVKQY 326_ GPNSP 331_ YMRTL 336_ LDSIA 341_ HGHRL 346_ IPYDW 351_ EILAK 356_ SSLSP 361_ SQFLQ 366_ FKTWW 371_ IDGVQ 376_ EQVRR 381_ NRAAN 386_ PPVNI 391_ DADQL 396_ LGIGQ 401_ NWSTI 406_ SQQAL 411_ MQNEA 416_ IEQVR 421_ AICLR 426_ AWEKI 431_ QDPGS 436_ TCPSF 441_ NTVRQ 446_ GSKEP 451_ YPDFV 456_ ARLQD 461_ VAQKS 466_ IADEK 471_ ARKVI 476_ VELMA 481_ YENAN 486_ PECQS 491_ AIKPL 496_ KGKVP 501_ AGSDV 506_ ISEYV 511_ KACDG 516_ IGGAM 521_ HKAML 526_ MAQAI 531_ TGVVL 536_ GGQVR 541_ TFGGK 546_ CYNCG 551_ QIGHL 556_ KKNCP 561_ VLNKQ 566_ NITIQ 571_ ATTTG 576_ REPPD 581_ LCPRC 586_ KKGKH 591_ WASQC 596_ RSKFD 601_ KNGQP 606_ LSGNE 611_ QRGQP 616_ QAPQQ 621_ TGAFP 626_ IQPFV 631_ PQGFQ 636_ GQQPP 641_ LSQVF 646_ QGISQ 651_ LPQYN 656_ NCPPP 661_ QVAVQ 666_ QVDLC 671_ TIQAV 676_ SLLPG 681_ EPPQK 686_ IPTGV 691_ YGPLP 696_ EGTVG 701_ LILGR 706_ SSLNL 711_ KGVQI 716_ HTSVV 721_ DSDYK 726_ GEIQL 731_ VISSS 736_ VPWSA 741_ SPGDR 746_ IAQLL 751_ LLPYI 756_ KGGNS 761_ EIKRI 766_ GGLGS 771_ TDPTG 776_ KAAYW 781_ ASQVS 786_ ENRPV 791_ CKAII 796_ QGKQF 801_ EGLVD 806_ TGADV 811_ SIIAL 816_ NQWPK 821_ NWPKQ 826_ KAVTG 831_ LVGIG 836_ TASEV 841_ YQSME 846_ ILHCL 851_ GPDNQ 856_ ESTVQ 861_ PMITS 866_ IPLNL 871_ WGRDL 876_ LQQWG 881_ AEITM 886_ PAPLY 891_ SPTSQ 896_ KIMTK 901_ RGYIP 906_ GKGLG 911_ KNEDG 916_ IKIPF 921_ EAKIN 926_ QKREG 931_ IGYPF 936_ LGAAT 941_ IEPPK 946_ PIPLT 951_ WKTEK 956_ PVWVN 961_ QWPLP 966_ KQKLE 971_ ALHLL 976_ ANEQL 981_ EKGHI 986_ EPSFS 991_ PWNSP 996_ VFVIQ 1001_ KKSGK 1006_ WRMLT 1011_ DLRAV 1016_ NAVIQ 1021_ PMGPL 1026_ QPGLP 1031_ SPAMI 1036_ PKDWP 1041_ LIIID 1046_ LKDCF 1051_ FTIPL 1056_ AEQDC 1061_ EKFAF 1066_ TIPAI 1071_ NNKEP 1076_ ATRFQ 1081_ WKVLP 1086_ QGMLN 1091_ SPTIC 1096_ QTFVG 1101_ RALQP 1106_ VKVFR 1111_LLYYS
1: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution (By similarity)
2: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity)