Endogenous retrovirus group K member 8 Pol protein (HERV-K115 Pol protein) (HERV-K_8p23.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
1_NKSKK 6_ RRNRV 11_ SFLGV 16_ ATIEP 21_ PKPIP 26_ LTWKT 31_ EKLVW 36_ VNQWP 41_ LPKQK 46_ LEALH 51_ LLANE 56_ QLEKG 61_ HIEPS 66_ FSPWN 71_ SPVFV 76_ IQKKS 81_ GKWRM 86_ LTDLR 91_ AVNAV 96_ IQPMG 101_ PLQPG 106_ LPSPA 111_ MIPKD 116_ WPLII 121_ IDLKD 126_ CFFTI 131_ PLAEQ 136_ DCEKF 141_ AFTIP 146_ AINNK 151_ EPATR 156_ FQWKV 161_ LPQGM 166_ LNSPT 171_ ICQTF 176_ VGRAL 181_ QPVRK 186_ KFSDC 191_ YIIHY 196_ IDDIL 201_ CAAET 206_ KDKLI 211_ DCYTF 216_ LQAEV 221_ ASAGL 226_ AIASD 231_ KIQTS 236_ TPFHY 241_ LGMQI 246_ ENRKI 251_ KPQKI 256_ EIRKD 261_ TLKTL 266_ NDFQK 271_ LLGDI 276_ NWIQP 281_ TLGIP 286_ TYAMS 291_ NLFSI 296_ LRGDS 301_ DLNSK 306_ RILTP 311_ EATKE 316_ IKLVE 321_ EKIQS 326_ AQINR 331_ IDPLA 336_ PLQLL 341_ IFATA 346_ HSPTG 351_ IIIQN 356_ TDLVE 361_ WSFLP 366_ HSTVK 371_ TFTLY 376_ LDQIA 381_ TLIGQ 386_ TRLRI 391_ IKLCG 396_ NDPDK 401_ IVVPL 406_ TKEQV 411_ RQAFI 416_ NSGAW 421_ QIGLA 426_ NFVGI 431_ IDNHY 436_ PKTKI 441_ FQFLK 446_ LTTWI 451_ LPKIT 456_ RREPL 461_ ENALT 466_ VFTDG 471_ SSNGK 476_ AAYTG 481_ PKERV 486_ IKTPY 491_ QSAQR 496_ AELVA 501_ VITVL 506_ QDFDQ 511_ PINII 516_ SDSAY 521_ VVQAT 526_ RVVET 531_ ALIKY 536_ SMDDQ 541_ LNQLF 546_ NLLQQ 551_ TVRKR 556_ NFPFY 561_ ITHIR 566_ AHTNL 571_ PGPLT 576_ KANEQ 581_ ADLLV 586_ SSALI 591_ KAQEL 596_ HALTH 601_ VNAAG 606_ LKNKF 611_ DVTWK 616_ QAKDI 621_ VQHCT 626_ QCQVL 631_ HLPTQ 636_ EAGVN 641_ PRGLC 646_ PNALW 651_ QMDVT 656_ HVPSF 661_ GRLSY 666_ VHVTV 671_ DTYSH 676_ FIWAT 681_ CQTGE 686_ STSHV 691_ KKHLL 696_ SCFAV 701_ MGVPE 706_ KIKTD 711_ NGPGY 716_ CSKAF 721_ QKFLS 726_ QWKIS 731_ HTTGI 736_ PYNSQ 741_ GQAIV 746_ ERTNR 751_ TLKTQ 756_ LVKQK 761_ EGGDS 766_ KECTT 771_ PQMQL 776_ NLALY 781_ TLNFL 786_ NIYRN 791_ QTTTS 796_ AEQHL 801_ TGKKN 806_ SPHEG 811_ KLIWW 816_ KDNKN 821_ KTWEI 826_ GKVIT 831_ WGRGF 836_ ACVSP 841_ GENQL 846_ PVWIP 851_ TRHLK 856_ FYNEP 861_ IRDAK 866_ KSTSA 871_ ETETP 876_ QSSTV 881_ DSQDE 886_ QNGDV 891_ RRTDE 896_ VAIHQ 901_ EGRAA 906_ DLGTT 911_ KEADA 916_ VSYKI 921_ SREHK 926_ GDTNP 931_ REYAA 936_ CSLDD 941_ CINGG 946_ KSPYA 951_CRSSC
1: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution