Endogenous retrovirus group K member 7 Pol protein (HERV-K(III) Pol protein) (HERV-K102 Pol protein) (HERV-K_1q22 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
1_NKSRK 6_ RRNRL 11_ SFLGA 16_ ATVEP 21_ PKPIP 26_ LTWKT 31_ EKPVW 36_ VNQWP 41_ LPKQK 46_ LEALH 51_ LLANE 56_ QLEKG 61_ HIEPS 66_ FSPWN 71_ SPVFV 76_ IQKKS 81_ GKWRM 86_ LTDLR 91_ AVNAV 96_ IQPMG 101_ PLQPG 106_ LPSPA 111_ MIPKD 116_ WPLII 121_ IDLKD 126_ CFFTI 131_ PLAEQ 136_ DCEKF 141_ AFTIP 146_ AINNK 151_ EPATR 156_ FQWKV 161_ LPQGM 166_ LNSPT 171_ ICQTF 176_ VGRAL 181_ QPVRE 186_ KFSDC 191_ YIIHY 196_ IDDIL 201_ CAAET 206_ RDKLI 211_ DCYTF 216_ LQAEV 221_ ANAGL 226_ AIASD 231_ KIQTS 236_ TPFHY 241_ LGMQI 246_ ENRKI 251_ KQQKI 256_ EIRKD 261_ TLKTL 266_ NDFQK 271_ LLGDI 276_ NWIRP 281_ TLGIP 286_ TYAMS 291_ NLFSI 296_ LRGDS 301_ DLNSK 306_ RILTP 311_ EATKE 316_ IKLVE 321_ EKIQS 326_ AQINR 331_ IDPLA 336_ PLQLL 341_ IFATA 346_ HSPTG 351_ IIIQN 356_ TDLVE 361_ WSFLP 366_ HSTVK 371_ TFTLY 376_ LDQIA 381_ TLIGQ 386_ TRLRI 391_ IKLCG 396_ NDPDK 401_ IVVPL 406_ TKEQV 411_ RQAFI 416_ NSGAW 421_ QIGLA 426_ NFVGI 431_ IDNHY 436_ PKTKI 441_ FQFLK 446_ LTTWI 451_ LPKIT 456_ RREPL 461_ ENALT 466_ VFTDG 471_ SSNGK 476_ AAYTG 481_ PKERV 486_ IKTPY 491_ QSAQR 496_ AELVA 501_ VITVL 506_ QDFDQ 511_ PINII 516_ SDSAY 521_ VVQAT 526_ RDVET 531_ ALIKY 536_ SMDDQ 541_ LNQLF 546_ NLLQQ 551_ TVRKR 556_ NFPFY 561_ ITHIR 566_ AHTNL 571_ PGPLT 576_ KANEQ 581_ ADLLV 586_ SSALI 591_ KAQEL 596_ HALTH 601_ VNAAG 606_ LKNKF 611_ DVTWK 616_ QAKDI 621_ VQHCT 626_ QCQIL 631_ HLPTQ 636_ EAGVN 641_ PRGLC 646_ PNALW 651_ QMDVT 656_ HVPSF 661_ GRLSY 666_ VHVTV 671_ DTYSH 676_ FIWAT 681_ CQTGE 686_ STSHV 691_ KKHLL 696_ SCFAV 701_ MGVPE 706_ KIKTD 711_ NGPGY 716_ CSKAF 721_ QKFLS 726_ QWKIS 731_ HTTGI 736_ PYNSQ 741_ GQAIV 746_ ERTNR 751_ TLKTQ 756_ LVKQK 761_ EGGDS 766_ KECTT 771_ PQMQL 776_ NLALY 781_ TLNFL 786_ NIYRN 791_ QTTTS 796_ AEQHL 801_ TGKKN 806_ SPHEG 811_ KLIWW 816_ KDNKN 821_ KTWEI 826_ GKVIT 831_ WGRGF 836_ ACVSP 841_ GENQL 846_ PVWIP 851_ TRHLK 856_ FYNEP 861_ IGDAK 866_ KRAST 871_ EMVTP 876_ VTWMD 881_ NPIEI 886_ YVNDS 891_ VWVPG 896_ PIDDR 901_ CPAKP 906_ EEEGM 911_ MINIS 916_ IGYRY 921_ PPICL 926_ GRAPG 931_ CLMPA 936_ VQNWL 941_ VEVPT 946_ VSPIS 951_ RFTYH 956_ MVSGM 961_ SLRPR 966_ VNYLQ 971_ DFSYQ 976_ RSLKF 981_ RPKGK 986_ PCPKE 991_ IPKES 996_ KNTEV 1001_ LVWEE 1006_ CVANS 1011_ AVILQ 1016_ NNEFG 1021_ TIIDW 1026_ APRGQ 1031_ FYHNC 1036_ SGQTQ 1041_ SCPSA 1046_ QVSPA 1051_ VDSDL 1056_ TESLD 1061_ KHKHK 1066_ KLQSF 1071_ YPWEW 1076_ GEKGI 1081_ STPRP 1086_ KIVSP 1091_ VSGPE 1096_ HPELW 1101_ RLTVA 1106_ SHHIR 1111_ IWSGN 1116_ QTLET 1121_ RDCKP 1126_ FYTID 1131_ LNSSL 1136_ TVPLQ 1141_ SCVKP 1146_ PYMLV 1151_ VGNIV 1156_ IKPDS 1161_ QTITC 1166_ ENCRL 1171_ LTCID 1176_ STFNW 1181_ QHRIL 1186_ LVRAR 1191_ EGVWI 1196_ PVSMD 1201_ RPWEA 1206_ SPSVH 1211_ ILTEV 1216_ LKGVL 1221_ NRSKR 1226_ FIFTL 1231_ IAVIM 1236_ GLIAV 1241_ TATAA 1246_ VAGVA 1251_ LHSSV 1256_ QSVNF 1261_ VNDWQ 1266_ KNSTR 1271_ LWNSQ 1276_ SSIDQ 1281_ KLANQ 1286_ INDLR 1291_ QTVIW 1296_ MGDRL 1301_ MSLEH 1306_ RFQLQ 1311_ CDWNT 1316_ SDFCI 1321_ TPQIY 1326_ NESEH 1331_ HWDMV 1336_ RRHLQ 1341_ GREDN 1346_ LTLDI 1351_ SKLKE 1356_ QIFEA 1361_ SKAHL 1366_ NLVPG 1371_ TEAIA 1376_ GVADG 1381_ LANLN 1386_ PVTWV 1391_ KTIGS 1396_ TTIIN 1401_ LILIL 1406_ VCLFC 1411_ LLLVC 1416_ RCTQQ 1421_ LRRDS 1426_ DHRER 1431_ AMMTM 1436_ AVLSK 1441_ RKGGN 1446_ VGKSK 1451_RDQIV
1: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution