Endogenous retrovirus group K member 25 Pol protein (HERV-K_11q22.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
1_NKSKK 6_ RRNRV 11_ SFLGA 16_ ATVEP 21_ PKPIP 26_ LTWKT 31_ EKPVW 36_ VNQWP 41_ LPKQK 46_ LEALH 51_ LLANE 56_ QLEKG 61_ HIEPS 66_ FSPWN 71_ SPVFV 76_ IQKKS 81_ GKWRM 86_ LTDLR 91_ AVNAV 96_ IQPMG 101_ PLQPG 106_ LPSPA 111_ MIPKD 116_ WPLII 121_ IDLKD 126_ CFFTI 131_ PLAEQ 136_ DCEKF 141_ AFTIP 146_ AINNK 151_ EPATR 156_ FQWKV 161_ LPQGM 166_ LNSPT 171_ ICQTF 176_ VGRAL 181_ QPVRE 186_ KFSDC 191_ YIIHY 196_ IDDIL 201_ CAAET 206_ KDKLI 211_ DCYTF 216_ LQAEV 221_ ANAGL 226_ AIASD 231_ KIQTS 236_ TPFHY 241_ LGMQI 246_ ENRKI 251_ KPQKI 256_ EIRKD 261_ TLKAL 266_ NDFQK 271_ LLGDI 276_ NWIRP 281_ TLGIP 286_ TYAMS 291_ NLFSI 296_ LRGDS 301_ DLNSK 306_ RMLTP 311_ EATKE 316_ IKLVE 321_ EKIQS 326_ AQINR 331_ IDPLA 336_ PLQLL 341_ IFATA 346_ HSPTG 351_ IIIQN 356_ TDLVE 361_ WSFLP 366_ HSTVK 371_ TFTLY 376_ LDQIA 381_ TLIGQ 386_ TRLRI 391_ IKLCG 396_ NDPDK 401_ IVVPL 406_ TKEQV 411_ RQAFI 416_ NSGAW 421_ QIGLA 426_ NFVGI 431_ IDNHY 436_ PKTKI 441_ FQFLK 446_ LTTWI 451_ LPKIT 456_ RREPL 461_ ENALT 466_ VFTDG 471_ SSNGK 476_ AAYTG 481_ PKERV 486_ IKTPY 491_ QSAQR 496_ AELVA 501_ VITVL 506_ QDFDI 511_ NIISD 516_ SAYVV 521_ QATRD 526_ VETAL 531_ IKYSM 536_ DDQLN 541_ QLFNL 546_ LQQTV 551_ RKRNF 556_ PFYIT 561_ HIRAH 566_ TNLPG 571_ PLTKA 576_ NKQAD 581_ LLVSS 586_ ALIKA 591_ QELHA 596_ LTHVN 601_ AAGLK 606_ NKFDV 611_ TWKLA 616_ KDIVQ 621_ HCTQC 626_ QVLHL 631_ PTQEA 636_ GVNPR 641_ GLCPN 646_ ALWQM 651_ DVTHV 656_ PSFGR 661_ LSYVH 666_ VTVDT 671_ YSHFI 676_ WATCH 681_ TGEST 686_ SHVKK 691_ HLLSC 696_ FAVMG 701_ VPEKI 706_ KTDNG 711_ PGYCS 716_ KAFQK 721_ FLSQW 726_ KISHT 731_ TGIPY 736_ NSQGQ 741_ AIVER 746_ TNRTL 751_ KTQLV 756_ KQKEG 761_ GDSKE 766_ CTTPQ 771_ MQLNL 776_ ALYTL 781_ NFLNI 786_ YRNQT 791_ TTSAE 796_ QHLTG 801_ KKNSP 806_ HEGKL 811_ IWWKD 816_ NKNKT 821_ WEIGK 826_ VITWG 831_ RGFAC 836_ VSPGE 841_ NQLPV 846_ WIPTR 851_ HLKFY 856_ NEPIR 861_ DAKKS 866_ TSAET 871_ ETPQS 876_ STVDS 881_ QDEQN 886_ GDVRR 891_ TDEVA 896_ IHQEG 901_ RAANL 906_ GTTKE 911_ ADAVS 916_ YKISR 921_ EHKGD 926_ TNPRE 931_ YAACS 936_ LDDCI 941_ NGGKS 946_PYACR
1: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity)