Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)
1_MAGAG 6_ GGNDI 11_ QWCFS 16_ QVKGA 21_ VDDDV 26_ AEADI 31_ ISTVE 36_ FNHSG 41_ ELLAT 46_ GDKGG 51_ RVVIF 56_ QQEQE 61_ NKIQS 66_ HSRGE 71_ YNVYS 76_ TFQSH 81_ EPEFD 86_ YLKSL 91_ EIEEK 96_ INKIR 101_ WLPQK 106_ NAAQF 111_ LLSTN 116_ DKTIK 121_ LWKIS 126_ ERDKR 131_ PEGYN 136_ LKEED 141_ GRYRD 146_ PTTVT 151_ TLRVP 156_ VFRPM 161_ DLMVE 166_ ASPRR 171_ IFANA 176_ HTYHI 181_ NSISI 186_ NSDYE 191_ TYLSA 196_ DDLRI 201_ NLWHL 206_ EITDR 211_ SFNIV 216_ DIKPA 221_ NMEEL 226_ TEVIT 231_ AAEFH 236_ PNSCN 241_ TFVYS 246_ SSKGT 251_ IRLCD 256_ MRASA 261_ LCDRH 266_ SKLFE 271_ EPEDP 276_ SNRSF 281_ FSEII 286_ SSISD 291_ VKFSH 296_ SGRYM 301_ MTRDY 306_ LSVKI 311_ WDLNM 316_ ENRPV 321_ ETYQV 326_ HEYLR 331_ SKLCS 336_ LYEND 341_ CIFDK 346_ FECCW 351_ NGSDS 356_ VVMTG 361_ SYNNF 366_ FRMFD 371_ RNTKR 376_ DITLE 381_ ASREN 386_ NKPRT 391_ VLKPR 396_ KVCAS 401_ GKRKK 406_ DEISV 411_ DSLDF 416_ NKKIL 421_ HTAWH 426_ PKENI 431_ IAVAT 436_ TNNLY 441_IFQDK
1: Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758)