Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
1_MGSVR 6_ TNRYS 11_ IVSSE 16_ EDGMK 21_ LATMA 26_ VANGF 31_ GNGKS 36_ KVHTR 41_ QQCRS 46_ RFVKK 51_ DGHCN 56_ VQFIN 61_ VGEKG 66_ QRYLA 71_ DIFTT 76_ CVDIR 81_ WRWML 86_ VIFCL 91_ AFVLS 96_ WLFFG 101_ CVFWL 106_ IALLH 111_ GDLDA 116_ SKEGK 121_ ACVSE 126_ VNSFT 131_ AAFLF 136_ SIETQ 141_ TTIGY 146_ GFRCV 151_ TDECP 156_ IAVFM 161_ VVFQS 166_ IVGCI 171_ IDAFI 176_ IGAVM 181_ AKMAK 186_ PKKRN 191_ ETLVF 196_ SHNAV 201_ IAMRD 206_ GKLCL 211_ MWRVG 216_ NLRKS 221_ HLVEA 226_ HVRAQ 231_ LLKSR 236_ ITSEG 241_ EYIPL 246_ DQIDI 251_ NVGFD 256_ SGIDR 261_ IFLVS 266_ PITIV 271_ HEIDE 276_ DSPLY 281_ DLSKQ 286_ DIDNA 291_ DFEIV 296_ VILEG 301_ MVEAT 306_ AMTTQ 311_ CRSSY 316_ LANEI 321_ LWGHR 326_ YEPVL 331_ FEEKH 336_ YYKVD 341_ YSRFH 346_ KTYEV 351_ PNTPL 356_ CSARD 361_ LAEKK 366_ YILSN 371_ ANSFC 376_ YENEV 381_ ALTSK 386_ EEDDS 391_ ENGVP 396_ ESTST 401_ DTPPD 406_ IDLHN 411_ QASVP 416_ LEPRP 421_LRRES
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:7590287, PubMed:7696590). The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:9490857). Can be blocked by extracellular barium or cesium (PubMed:7590287, PubMed:7696590). Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (PubMed:7590287, PubMed:7696590, PubMed:7840300)