SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
1_MSGIA 6_ LSRLA 11_ QERKA 16_ WRKDH 21_ PFGFV 26_ AVPTK 31_ NPDGT 36_ MNLMN 41_ WECAI 46_ PGKKG 51_ TPWEG 56_ GLFKL 61_ RMLFK 66_ DDYPS 71_ SPPKC 76_ KFEPP 81_ LFHPN 86_ VYPSG 91_ TVCLS 96_ ILEED 101_ KDWRP 106_ AITIK 111_ QILLG 116_ IQELL 121_ NEPNI 126_ QDPAQ 131_ AEAYT 136_ IYCQN 141_ RVEYE 146_ KRVRA 151_QAKKF
1: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705)