Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)
1_MLSLD 6_ FLDDV 11_ RRMNK 16_ RQLYY 21_ QVLNF 26_ GMIVS 31_ SALMI 36_ WKGLM 41_ VITGS 46_ ESPIV 51_ VVLSG 56_ SMEPA 61_ FHRGD 66_ LLFLT 71_ NRVED 76_ PIRVG 81_ EIVVF 86_ RIEGR 91_ EIPIV 96_ HRVLK 101_ IHEKQ 106_ NGHIK 111_ FLTKG 116_ DNNAV 121_ DDRGL 126_ YKQGQ 131_ HWLEK 136_ KDVVG 141_ RARGF 146_ VPYIG 151_ IVTIL 156_ MNDYP 161_ KFKYA 166_ VLFLL 171_GLFVL
1: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369)