Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)
1_MSSSE 6_ EVSWI 11_ SWFCG 16_ LRGNE 21_ FFCEV 26_ DEDYI 31_ QDKFN 36_ LTGLN 41_ EQVPH 46_ YRQAL 51_ DMILD 56_ LEPDE 61_ ELEDN 66_ PNQSD 71_ LIEQA 76_ AEMLY 81_ GLIHA 86_ RYILT 91_ NRGIA 96_ QMLEK 101_ YQQGD 106_ FGYCP 111_ RVYCE 116_ NQPML 121_ PIGLS 126_ DIPGE 131_ AMVKL 136_ YCPKC 141_ MDVYT 146_ PKSSR 151_ HHHTD 156_ GAYFG 161_ TGFPH 166_ MLFMV 171_ HPEYR 176_ PKRPA 181_ NQFVP 186_ RLYGF 191_ KIHPM 196_ AYQLQ 201_ LQAAS 206_NFKSP
1: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity)
2: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition (PubMed:31341047)