Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
1_MAGLN 6_ SLEAV 11_ KRKIQ 16_ ALQQQ 21_ ADEAE 26_ DRAQG 31_ LQREL 36_ DGERE 41_ RREKA 46_ EGDVA 51_ ALNRR 56_ IQLVE 61_ EELDR 66_ AQERL 71_ ATALQ 76_ KLEEA 81_ EKAAD 86_ ESERG 91_ MKVIE 96_ NRAMK 101_ DEEKM 106_ EIQEM 111_ QLKEA 116_ KHIAE 121_ EADRK 126_ YEEVA 131_ RKLVI 136_ LEGEL 141_ ERAEE 146_ RAEVS 151_ ELKCG 156_ DLEEE 161_ LKNVT 166_ NNLKS 171_ LEAAS 176_ EKYSE 181_ KEDKY 186_ EEEIK 191_ LLSDK 196_ LKEAE 201_ TRAEF 206_ AERTV 211_ AKLEK 216_ TIDDL 221_ EEKLA 226_ QAKEE 231_ NVGLH 236_ QTLDQ 241_TLNEL
1: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis