Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)
1_MGKEK 6_ THINI 11_ VVIGH 16_ VDSGK 21_ STTTG 26_ HLIYK 31_ CGGID 36_ KRTIE 41_ KFEKE 46_ AAEMG 51_ KGSFK 56_ YAWVL 61_ DKLKA 66_ ERERG 71_ ITIDI 76_ SLWKF 81_ ETSKY 86_ YVTII 91_ DAPGH 96_ RDFIK 101_ NMITG 106_ TSQAD 111_ CAVLI 116_ VAAGV 121_ GEFEA 126_ GISKN 131_ GQTRE 136_ HALLA 141_ YTLGV 146_ KQLIV 151_ GVNKM 156_ DSTEP 161_ PYSQK 166_ RYEEI 171_ VKEVS 176_ TYIKK 181_ IGYNP 186_ DTVAF 191_ VPISG 196_ WNGDN 201_ MLEPS 206_ ANMPW 211_ FKGWK 216_ VTRKD 221_ GNASG 226_ TTLLE 231_ ALDCI 236_ LPPTR 241_ PTDKP 246_ LRLPL 251_ QDVYK 256_ IGGIG 261_ TVPVG 266_ RVETG 271_ VLKPG 276_ MVVTF 281_ APVNV 286_ TTEVK 291_ SVEMH 296_ HEALS 301_ EALPG 306_ DNVGF 311_ NVKNV 316_ SVKDV 321_ RRGNV 326_ AGDSK 331_ NDPPM 336_ EAAGF 341_ TAQVI 346_ ILNHP 351_ GQISA 356_ GYAPV 361_ LDCHT 366_ AHIAC 371_ KFAEL 376_ KEKID 381_ RRSGK 386_ KLEDG 391_ PKFLK 396_ SGDAA 401_ IVDMV 406_ PGKPM 411_ CVESF 416_ SDYPP 421_ LGRFA 426_ VRDMR 431_ QTVAV 436_ GVIKA 441_ VDKKA 446_ AGAGK 451_ VTKSA 456_QKAQK
1: Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity)
2: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection