Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)
1_MSQGD 6_ SNPAA 11_ IPHAA 16_ EDIQG 21_ DDRWM 26_ SQHNR 31_ FVLDC 36_ KDKEP 41_ DVLFV 46_ GDSMV 51_ QLMQQ 56_ YEIWR 61_ ELFSP 66_ LHALN 71_ FGIGG 76_ DTTRH 81_ VLWRL 86_ KNGEL 91_ ENIKP 96_ KVIVV 101_ WVGTN 106_ NHENT 111_ AEEVA 116_ GGIEA 121_ IVQLI 126_ NTRQP 131_ QAKII 136_ VLGLL 141_ PRGEK 146_ PNPLR 151_ QKNAK 156_ VNQLL 161_ KVSLP 166_ KLANV 171_ QLLDT 176_ DGGFV 181_ HSDGA 186_ ISCHD 191_ MFDFL 196_ HLTGG 201_ GYAKI 206_ CKPLH 211_ ELIMQ 216_ LLEET 221_PEEKQ
1: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity)