UBX domain-containing protein 2A (UBX domain-containing protein 4)
1_MKDVD 6_ NLKSI 11_ KEEWV 16_ CETGS 21_ DNQPL 26_ GNNQQ 31_ SNCEY 36_ FVDSL 41_ FEEAQ 46_ KVSSK 51_ CVSPA 56_ EQKKQ 61_ VDVNI 66_ KLWKN 71_ GFTVN 76_ DDFRS 81_ YSDGA 86_ SQQFL 91_ NSIKK 96_ GELPS 101_ ELQGI 106_ FDKEE 111_ VDVKV 116_ EDKKN 121_ EICLS 126_ TKPVF 131_ QPFSG 136_ QGHRL 141_ GSATP 146_ KIVSK 151_ AKNIE 156_ VENKN 161_ NLSAV 166_ PLNNL 171_ EPITN 176_ IQIWL 181_ ANGKR 186_ IVQKF 191_ NITHR 196_ VSHIK 201_ DFIEK 206_ YQGSQ 211_ RSPPF 216_ SLATA 221_ LPVLR 226_ LLDET 231_ LTLEE 236_ ADLQN 241_ AVIIQ 246_ RLQKT 251_ASFRE
1: Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (PubMed:24625977, PubMed:26634371). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (PubMed:37037900)