Gene name: HBB

Uniprot entry:

P68871

Protein names:

Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]

Protein sequence:

1_MVHLT 6_ PEEKS 11_ AVTAL 16_ WGKVN 21_ VDEVG 26_ GEALG 31_ RLLVV 36_ YPWTQ 41_ RFFES 46_ FGDLS 51_ TPDAV 56_ MGNPK 61_ VKAHG 66_ KKVLG 71_ AFSDG 76_ LAHLD 81_ NLKGT 86_ FATLS 91_ ELHCD 96_ KLHVD 101_ PENFR 106_ LLGNV 111_ LVCVL 116_ AHHFG 121_ KEFTP 126_ PVQAA 131_ YQKVV 136_ AGVAN 141_ALAHK

Protein annotations

Protein functions:

1: Involved in oxygen transport from the lung to the various peripheral tissues

2: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure

3: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation