Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)
1_MALLL 6_ CFVLL 11_ CGVVD 16_ FARSL 21_ SITTP 26_ EEMIE 31_ KAKGE 36_ TAYLP 41_ CKFTL 46_ SPEDQ 51_ GPLDI 56_ EWLIS 61_ PADNQ 66_ KVDQV 71_ IILYS 76_ GDKIY 81_ DDYYP 86_ DLKGR 91_ VHFTS 96_ NDLKS 101_ GDASI 106_ NVTNL 111_ QLSDI 116_ GTYQC 121_ KVKKA 126_ PGVAN 131_ KKIHL 136_ VVLVK 141_ PSGAR 146_ CYVDG 151_ SEEIG 156_ SDFKI 161_ KCEPK 166_ EGSLP 171_ LQYEW 176_ QKLSD 181_ SQKMP 186_ TSWLA 191_ EMTSS 196_ VISVK 201_ NASSE 206_ YSGTY 211_ SCTVR 216_ NRVGS 221_ DQCLL 226_ RLNVV 231_ PPSNK 236_ AGLIA 241_ GAIIG 246_ TLLAL 251_ ALIGL 256_ IIFCC 261_ RKKRR 266_ EEKYE 271_ KEVHH 276_ DIRED 281_ VPPPK 286_ SRTST 291_ ARSYI 296_ GSNHS 301_ SLGSM 306_ SPSNM 311_ EGYSK 316_ TQYNQ 321_ VPSED 326_ FERTP 331_ QSPTL 336_ PPAKV 341_ AAPNL 346_ SRMGA 351_ IPVMI 356_PAQSK
1: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair
2: (Microbial infection) Acts as a receptor for adenovirus type C
3: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6